Drugs info

Posted on May 20, 2012 by admin

Drugs Summary

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Sprycel for Cancer Treatment

Posted on May 18, 2012 by admin

Sprycel contains dasatinib used to treat certain types of cancer. How it works by slowingor stopping cancer cell growth. It may also be used for other conditions as determined by your doctor.

Sprycel is a tyrosine kinase inhibitor. It works by blocking proteins that cause the rapid growth of certain types of leukemia cells. This helps the bone marrow to start making normal blood cells again.

Some can react with Sprycel. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, heparin, warfarin), antiplatelet medicines (eg, clopidogrel), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding problems may be increased
  • Anthracyclines (eg, doxorubicin), antiarrhythmics (eg, amiodarone, quinidine), arsenic, astemizole, bepridil, chloroquine, citalopram, cisapride, crizotinib, dolasetron, domperidone, doxepin, droperidol, halofantrine, haloperidol, iloperidone, maprotiline, methadone, nortriptyline, ondansetron, paliperidone, pentamidine, phenothiazines (eg, thioridazine), pimozide, quetiapine, quinolone antibiotics (eg, levofloxacin), romidepsin, tacrolimus, terfenadine, toremifene, vandetanib, or ziprasidone because the risk of severe and possibly fatal irregular heartbeat may be increased
  • Azole antifungals (eg, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, protease inhibitors (eg, boceprevir, ritonavir), or telithromycin because they may increase the risk of Sprycel’s side effects
  • Carbamazepine, dexamethasone, H2 blockers (eg, famotidine), hydantoins (eg, phenytoin), nevirapine, phenobarbital, primidone, proton pump inhibitors (eg, omeprazole), rifamycins (eg, rifabutin, rifampin), or St. John’s wort because they may decrease Sprycel’s effectiveness
  • Alfentanil, cyclosporine, ergot derivatives (eg, ergotamine), fentanyl, or sirolimus because the risk of their side effects may be increased by Sprycel

Indication

Drug used to treat myeloid leukemia and chronic lymphoblastic leukemia.

Dose

Sprycel taken orally once daily with or without food as directed by your doctor. Attention for you that this Sprycel drugs or this medicine should be swallowed whole and not cut, or crush tablets. Avoid taking antacidswithin 2 hours before or after using this medicine because it will reduce its effectiveness.Dosage is based on medical conditions, laboratory tests, response to treatment, andother medications you may take. Do not increase your dose or take this medicine moreoften than prescribed by your doctor. Because this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should nothandle this medication or breathe the dust from the tablets
Composition

Containing dasatinib

References

Jiang Q, Jiang B, Chen SS, et al.
[Pregnancy outcome among patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors]. [English Abstract, Journal Article]
Zhonghua Xue Ye Xue Za Zhi 2012 Jan; 33(1):6-9.
Abstract | Full Citation |
Sánchez-Bailón MP, Calcabrini A, Gómez-Domínguez D, et al.
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells. [Journal Article, Research Support, Non-U.S. Gov't]
Cell Signal 2012 Jun; 24(6):1276-86.
Abstract | Full Citation | Find Related Articles
Loveman E, Cooper K, Bryant J, et al.
Dasatinib, high-dose imatinib and nilotinib for the treatment of imatinib-resistant chronic myeloid leukaemia: a systematic review and economic evaluation. [Journal Article]
Health Technol Assess 2012 May; 16(23):1-138.
Abstract | Full Citation | Publisher Full Text |
Herrmann H, Blatt K, Ghanim V, et al.
Glucocorticosteroids Rescue Basophils from Dasatinib-Augmented Immunoglobulin E-Mediated Histamine Release. [JOURNAL ARTICLE]
Int Arch Allergy Immunol 2012 Apr 27; 159(1):15-22.
Abstract | Full Citation | Publisher Full Text |
Shapira S, Granot G, Mor-Tzuntz R, et al.
Second-generation tyrosine kinase inhibitors reduce telomerase activity in K562 cells. [JOURNAL ARTICLE]
Cancer Lett 2012 Apr 30.
Abstract | Full Citation | Publisher Full Text |
Posted in Cancer | Leave a comment

Quinupristin/Dalfopristin Antibitic Summary

Posted on May 17, 2012 by admin

Quinupristin is a streptogramin antibiotic that works by blocking the protein that release needed by bacteria to survive. Some drugs can interact with Quinupristin/Dalfopristin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, amiodarone, disopyramide, quinidine), astemizole, bepridil, calcium channel blockers (eg, diltiazem, nifedipine, verapamil), carbamazepine, cisapride, cyclosporine, diazepam, docetaxel, HIV protease inhibitors (eg, indinavir, ritonavir), HMG-CoA reductase inhibitors (“statins”) (eg, lovastatin), ketolides (eg, telithromycin), macrolides (eg, clarithromycin, erythromycin), methylprednisolone, midazolam, nonnucleoside reverse transcriptase inhibitors (NNRTIs) (eg, delavirdine, nevirapine), paclitaxel, pimozide, tacrolimus, terfenadine, vinca alkaloids (eg, vinblastine), or ziprasidone because the risk of their side effects may be increased by Quinupristin/Dalfopristin

Indications:

Treating serious life-threatening infections, caused by certain bacteria.

Side Effects:

  • GI Effects (N / V, diarrhea, antibiotic associated with diarrhea / colitis),
  •  CNS effectsheadache), hypersensitivity reactions (pruritus, rash, anaphylaxis is quite rare),
  • hematologic effects (anemia, eosinophilia, leukopenia, neutropenia);
  •  Effect muskoskeletal (myalgia, arthralgia that has occurred can be improved by reducing thefrequency of dosing);
  •  hepatic effects.

Special Instructions:

1. Contraindicated in patients with acute liver damage.
2. Use with caution in patients with liver dysfunction.
3. Could lead to the extension of wavelength QT (QT interval), use with caution in patientswith cardiac arrhythmia.

Special Instructions:

1. Contraindicated in patients with acute liver damage.
2. Use with caution in patients with liver dysfunction.
3. Could lead to the extension of wavelength QT (QT interval), use with caution in patientswith cardiac arrhythmia.

 References

Tremblay CL, Letellier A, Quessy S, et al.
Multiple-antibiotic resistance of Enterococcus faecalis and Enterococcus faecium from cecal contents in broiler chicken and turkey flocks slaughtered in Canada and plasmid colocalization of tetO and ermB genes. [Journal Article, Research Support, Non-U.S. Gov't]
J Food Prot 2011 Oct; 74(10):1639-48.
Abstract | Full Citation | Publisher Full Text |
Kelman A, Soong YA, Dupuy N, et al.
Antimicrobial susceptibility of Staphylococcus aureus from retail ground meats. [Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.]
J Food Prot 2011 Oct; 74(10):1625-9.
Abstract | Full Citation | Publisher Full Text |
Sancak B
[Staphylococcus aureus and antibiotic resistance]. [English Abstract, Journal Article, Review]
Mikrobiyol Bul 2011 Jul; 45(3):565-76.
Abstract | Full Citation |
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Loperamide For Diarrhea Treatment

Posted on May 15, 2012 by admin

A number of the adverse events reported during the clinical investigations and postmarketing experience with Loperamide are frequent symptoms of the underlying diarrheal syndrome (abdominal pain/discomfort, nausea, vomiting, dry mouth, tiredness, drowsiness, dizziness, constipation, and flatulence). These symptoms are often difficult to distinguish from undesirable drug effects.

Indication
Diarrhea.

Contra Indication on Acute diarrhea associated with the entry of organisms through the intestinal mucosa orpseudomembranous colitis associated with broad-spectrum antibiotics.
Baby.

Caution
Discontinue use if within 48 hours of no change.
Children under 2 years old.
Liver dysfunction.
Inflammatory bowel disease.

Side Effect
Abdominal pain, toxic megacolon, dry mouth, dizziness, fatigue, redness of the skin.

Caution :
B: Neither animal reproductive studies show no risk to the fetus as well as controlled studies in pregnant women or experimental animals showed no adverse effects (except for a decrease in fertility) where there are no controlled studies that confirm the risk in the first half of pregnant women (and no evidence of risk to the trimester hereinafter).

Packaging
Film-coated tablets 2 mg x 60 points.

Dosage
Adults: initial dose of 2 tablets and 1 tablet after each bowel movement.
Children: 100 mcg / kg body weight.
Maximum of 4-6 tablets per day.

Presentation

Taken with food or not

Composition
Loperamide HCl.
References

Chumakova YA, Bashkatova VG, Sudakov SK
Changes in feeding behavior after peripheral loperamide administration in rats. [Journal Article, Research Support, Non-U.S. Gov't]
Bull Exp Biol Med 2011 Feb; 150(4):398-400.
Abstract | Full Citation |
Lee HY, Kim JH, Jeung HW, et al.
Effects of Ficus carica paste on loperamide-induced constipation in rats. [Journal Article]
Food Chem Toxicol 2012 Mar; 50(3-4):895-902.
Abstract | Full Citation | Publisher Full Text |
Zhou Y, Sridhar R, Shan L, et al.
Loperamide, an FDA-approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity. [Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.]
Cancer Invest 2011 Feb; 30(2):119-25.
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Nabilone

Posted on May 15, 2012 by admin

This Nabilone information is a summary only. It does not contain all information about Nabilone. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Nabilone is used to treat nausea and vomiting during chemotherapy drug use. This drug is only used if the drug used to treat nausea and vomiting, other types do not work. It works by lowering the signal to the brain that encourages nausea and vomiting.

Some medicines may be interact with Nabilone. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Amphetamines, anticholinergics (eg, atropine, scopolamine), antihistamines (eg, diphenhydramine), cocaine, sympathomimetics (eg, albuterol, pseudoephedrine), or tricyclic antidepressants (eg, amitriptyline) because the risk of high blood pressure, heart problems (eg, fast heartbeat), or severe drowsiness may be increased
  • Barbiturates (eg, phenobarbital), benzodiazepines (eg, diazepam), buspirone, certain narcotic pain medicines (eg, morphine, codeine), lithium, muscle relaxants (eg, cyclobenzaprine), or phenothiazines (eg, chlorpromazine) because the risk of severe drowsiness may be increased
  • Disulfiram, fluoxetine, or naltrexone because the risk of mental or mood changes may be increased
  • Antipyrine because the risk of its side effects may be increased by Nabilone
  • Theophylline because its effectiveness may be decreased by Nabilone

Indication

To treat nausea and vomiting during chemotherapy drug use.

Side Effect

Change in appetite; confusion; decreased coordination; dizziness; drowsiness; dry mouth; elevated or relaxed mood; headache; nausea; trouble concentrating; trouble sleeping; weakness.

Dose

The dose is determined by patient response to chemotherapy treatment. For adult patients usually 1-2 mg twice a day with your doctor’s instructions while for pediatric patients the dose prescribed by your doctor.

References

Guindon J
Nabilone in inflammatory pain: to be or not to be. [Comment, Editorial]
Clin Exp Pharmacol Physiol 2012 Apr; 39(4):327-8.
Full Citation |
Todaro B
Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting. [Journal Article]
J Natl Compr Canc Netw 2012 Apr 1; 10(4):487-92.
Abstract | Full Citation | Publisher Full Text |
Sagredo O, Pazos MR, Valdeolivas S, et al.
Cannabinoids: novel medicines for the treatment of Huntington’s disease. [Journal Article, Research Support, Non-U.S. Gov't]
Recent Pat CNS Drug Discov 2012 Apr 1; 7(1):41-8.
Abstract | Full Citation | Publisher Full Text |
Bedi G, Cooper ZD, Haney M
Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers. [JOURNAL ARTICLE]
Addict Biol 2012 Jan 19.
Abstract | Full Citation | Publisher Full Text |
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